Abstract #4680
A FMRI GRAPH THEORY STUDY OF THE EFFECT OF GENDER AND AGING ON TOPOLOGY OF FUNCTIONAL BRAIN NETWORKS
Paola Valsasina 1 , Maria A. Rocca 1 , Alessandro Meani 1 , Francesco Mele 1 , Federica Agosta 1 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy
Using graph theoretical analysis, we analyzed the
combined effects of age and gender on large-scale
functional brain networks. Significant age-related
abnormalities were detected in both genders. Males
showed higher average network values than females. Both
genders experienced a significant age-related decline of
nodal degree and local efficiency of several regions of
the frontal lobe, temporal regions, posterior cingulate
cortex/precuneus and deep gray matter nuclei. The
age-related decline of functional network connectivity
measures in both genders might contribute to clarify
fundamental pathophysiologic aspects of healthy aging.
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