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Abstract #4697

Multivariate Patterns of Age-Associated Microstructural Change Measured by Diffusion Kurtosis Imaging

Jean-Philippe Coutu 1,2 , H. Diana Rosas 2 , and David Salat 2,3

1 Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 2 MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, MA, United States, 3 VA Boston Healthcare System, MA, United States

Age-associated white matter degeneration has previously been investigated using techniques such as diffusion tensor imaging (DTI). Diffusion kurtosis imaging (DKI), an extension of DTI, accounts for non-Gaussian water diffusion and can reflect alterations in the distribution and diffusion properties of tissue compartments. Little work so far has focused on combining diffusion measures to understand how age affects white matter regionally. We show here that a combination of DTI and DKI metrics enables the classification of white matter regions according to specific multivariate patterns of age-associated changes that might be representative of different types of microstructural pathology in brain aging.

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