Abstract #4697
Multivariate Patterns of Age-Associated Microstructural Change Measured by Diffusion Kurtosis Imaging
Jean-Philippe Coutu 1,2 , H. Diana Rosas 2 , and David Salat 2,3
1
Health Sciences and Technology,
Massachusetts Institute of Technology, Cambridge, MA,
United States,
2
MGH/HST
Athinoula A. Martinos Center for Biomedical Imaging, MA,
United States,
3
VA
Boston Healthcare System, MA, United States
Age-associated white matter degeneration has previously
been investigated using techniques such as diffusion
tensor imaging (DTI). Diffusion kurtosis imaging (DKI),
an extension of DTI, accounts for non-Gaussian water
diffusion and can reflect alterations in the
distribution and diffusion properties of tissue
compartments. Little work so far has focused on
combining diffusion measures to understand how age
affects white matter regionally. We show here that a
combination of DTI and DKI metrics enables the
classification of white matter regions according to
specific multivariate patterns of age-associated changes
that might be representative of different types of
microstructural pathology in brain aging.
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