Abstract #4698
Age-related increased R2 and R2* in the C57BL/6J mouse Basal Ganglia correlated with elevated iron levels measured by synchrotron-radiation X-ray fluorescence
Thomas Walker 1 , Christos Michaelides 1 , Harry Parkes 2 , William Crum 1 , Amy Herlihy 3 , and Po-Wah So 1
1
Department of Neuroimaging, Institute of
Psychiatry, King's College London, London, United
Kingdom,
2
CR-UK
Clinical MR Research Group, Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
3
Agilent
technologies, Yarnton, Oxfordshire, United Kingdom
Brain iron accumulation with ageing may play a role in
senescent processes, with age-related increases in basal
ganglia R2 and R2* observed in man and associated with
increased iron. Here, we show similar increases in R2
and R2* values of the basal ganglia in aged C57BL/6J
mice compared to young. Subsequent direct measurement of
iron by synchrotron radiation X-ray fluorescence
elemental iron mapping suggests the increased R2 and R2*
values here may indeed arise from higher iron
concentrations in this region. Thus, iron dyshomeostasis
may play a role in ageing and MR relaxometry may be used
to monitor ageing processes.
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