Abstract #4705
Mapping Gray Matter Structural Integrity in Adults Perinatally infected with HIV
Varan Govind 1 , Anai Cuadra 2 , Elizabeth Willen 2 , M Judy D Post 1 , Kristopher Arheart 3 , and Sulaiman Sheriff 1
1
Radiology, University of Miami, Miami,
Florida, United States,
2
Pediatrics,
University of Miami, Miami, Florida, United States,
3
Epidemiology
and Public Health, University of Miami, Miami, Florida,
United States
The long term impact of HIV infection and the potential
effects of its therapeutics on the brain are not
completely characterized. Previous brain imaging studies
have assessed only the changes in white matter and some
deep gray matter structures. In this study, all gray
matter structures within the brain are evaluated using
diffusion kurtosis imaging metrics in adults perinatally
infected with HIV and a matched control group for
comparisons. The results indicate significant changes in
19 of the 60 gray matter structures evaluated. These
changes may indicate underlying pathologies responsible
for HIV-associated neurocognitive disorder (HAND) in
people with HIV infection.
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