Abstract #4707
Early evidence of disease onset by in vivo MRI in a model of ALS
Linda Chaabane 1 , Nilo Riva 1 , Caterina Bendotti 2 , Angelo Quattrini 1 , and Giancarlo Comi 1
1
INSPE, San Raffaele Scientific Institute,
Milano, Italy,
2
Laboratory
of Molecular Neurobiology, Dept of Neuroscience, Mario
Negri Institute for Pharmacological Research, Milano,
Italy
In this study, the progression of peripheral nervous
system damage was monitored in the hSOD-1G93A rat model
of ALS by in vivo MRI. Both T2 relaxation time and DTI
parameters were analyzed from the preclinical onset to
advanced stage of degeneration. This in vivo follow-up
of disease progression allowed the definition of T2
relaxation time as a high sensitive marker of early
nerve alterations as detected at asymptomatic stage. T2
increase correlated to degenerating nerve fibers
associated to endoneurial oedema.
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