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Abstract #4707

Early evidence of disease onset by in vivo MRI in a model of ALS

Linda Chaabane 1 , Nilo Riva 1 , Caterina Bendotti 2 , Angelo Quattrini 1 , and Giancarlo Comi 1

1 INSPE, San Raffaele Scientific Institute, Milano, Italy, 2 Laboratory of Molecular Neurobiology, Dept of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy

In this study, the progression of peripheral nervous system damage was monitored in the hSOD-1G93A rat model of ALS by in vivo MRI. Both T2 relaxation time and DTI parameters were analyzed from the preclinical onset to advanced stage of degeneration. This in vivo follow-up of disease progression allowed the definition of T2 relaxation time as a high sensitive marker of early nerve alterations as detected at asymptomatic stage. T2 increase correlated to degenerating nerve fibers associated to endoneurial oedema.

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