Effects of COMT Val 158 Met Polymorphism on Resting State Brain Connectivity in HIV Infection and Aging
Linda Chang 1 , Caroline S. Jiang 1 , Vanessa Douet 1 , Eric T Cunningham 1 , Nataliya Holmes 1 , Ahnate Lim 2 , Xin Zhang 1 , and Thomas Ernst 1
Department of Medicine (Neurology),
University of Hawaii at Manoa, John A. Burns School of
Medicine, Honolulu, Hawaii, United States,
of Psychology, University of Hawaii at Manoa, Honolulu,
Hawaii, United States
Despite effective antiretroviral medications for HIV
viral suppression in the plasma, milder forms of
HIV-associated neurocognitive disorders (HAND) remain
prevalent. Polymorphism of the Val
the Catechol-O-Methyltransferase (
) gene may
play an important role in the development of HAND. 83
participants (40 HIV+ subjects and 43 HIV-seronegative
controls) were studied using resting state fMRI to
evaluate age-dependent changes in functional
connectivity (rs-fcMRI) in relation to the
HIV subjects with Met/Met alleles had the steepest and
greater than normal age-dependent decline in rs-fcMRI.
combined with rsfcMRI may be useful for predicting which
patient may develop HAND.
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