Abstract #4708
Effects of COMT Val 158 Met Polymorphism on Resting State Brain Connectivity in HIV Infection and Aging
Linda Chang 1 , Caroline S. Jiang 1 , Vanessa Douet 1 , Eric T Cunningham 1 , Nataliya Holmes 1 , Ahnate Lim 2 , Xin Zhang 1 , and Thomas Ernst 1
1
Department of Medicine (Neurology),
University of Hawaii at Manoa, John A. Burns School of
Medicine, Honolulu, Hawaii, United States,
2
Department
of Psychology, University of Hawaii at Manoa, Honolulu,
Hawaii, United States
Despite effective antiretroviral medications for HIV
viral suppression in the plasma, milder forms of
HIV-associated neurocognitive disorders (HAND) remain
prevalent. Polymorphism of the Val
158
Met for
the Catechol-O-Methyltransferase (
COMT
) gene may
play an important role in the development of HAND. 83
participants (40 HIV+ subjects and 43 HIV-seronegative
controls) were studied using resting state fMRI to
evaluate age-dependent changes in functional
connectivity (rs-fcMRI) in relation to the
COMT
genotypes.
HIV subjects with Met/Met alleles had the steepest and
greater than normal age-dependent decline in rs-fcMRI.
COMT
genotype
combined with rsfcMRI may be useful for predicting which
patient may develop HAND.
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