In-vivo detection of dopamine in the substantia nigra using 3D MRSI
Adriane Grger 1,2 , Rupert Kolb 2 , and Uwe Klose 2
Department of Neurology and Neuroimaging
Center (NIC), Mainz, Germany,
of Diagnostic and Interventional Neuroradiology,
Magnetic Resonance Research Group, Tbingen, Germany
Progressive degeneration of dopamine-producing neurons
within the substantia nigra pars compacta in Parkinson's
disease may be caused by mitochondrial dysfunction and
oxidative stress which can also explain our MRSI
findings of reduced NAA, creatine, glutathione and
dopamine as well as elevated taurine, GABA and glutamate
in the region of the substantia nigra.
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