Abstract #4710
Characterization of water transportation via aquaporin using tri-exponential model in cerebral infarction and Parkinson's disease - preliminary study
Xueying Ling 1 , Zhongping Zhang 2 , Zhoushe Zhao 2 , Lian Huang 3 , Yusheng Zhang 4 , Li Guo 5 , Yongjin Shi 6 , Changzheng Shi 6 , Li Huang 6 , and Hao Xu 6
1
medical imaging center, the first affiliated
hospital of Jinan university, Guangzhou, Guangdong,
China,
2
GE
healthcare, China, Guangdong, China,
3
neurology,
the first affiliated hospital of Jinan university,
Guangzhou, Guangdong, China,
4
neurology,
the first affiliated hospital of Jinan university,
Guangdong, China,
5
the
first affiliated hospital of Jinan university,
Guangdong, China,
6
medical
imaging center, the first affiliated hospital of Jinan
university, Guangdong, China
In biologic tissues, water molecules motion mainly
includes perfusion in the capillary network, diffusion
in the extracellular space, and the permeation in the
membrane by aquaporins. A triexponetial model based on
multiple b-value diffusion weighted imaging (mbDWI) has
theoretical advantages over currently available water
diffusion measurements. Because it is intrinsically
quantitative, and is mainly dependent on three
components hypothesis, i.e. capillary flow (fast
component), pure water diffusion (intermediate
component) and high b-value related diffusion (slow
component probably by aquaporins in the membrane).
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