Abstract #4738
More severe atrophy of basal nuclei in behavioral variant Frontotemporal Dementia compared to Alzheimers disease
Christiane Mller 1 , Nikki Dieleman 2 , Wiesje van der Flier 1,3 , Adriaan Versteeg 4 , Yolande Pijnenburg 1 , Philip Scheltens 1 , Frederik Barkhof 4 , and Hugo Vrenken 4,5
1
Neurology / Alzheimercenter, Neuroscience
Campus Amsterdam, VU University Medical center,
Amsterdam, Noord-Holland, Netherlands,
2
Radiology,
University Medical Center Utrecht, Utrecht, Utrecht,
Netherlands,
3
Epidemiology
& Biostatistics, Neuroscience Campus Amsterdam, VU
University Medical center, Amsterdam, Noord-Holland,
Netherlands,
4
Radiology
& Nuclear Medicine, Neuroscience Campus Amsterdam, VU
University Medical center, Amsterdam, Noord-Holland,
Netherlands,
5
Physics
& Medical Technology, Neuroscience Campus Amsterdam, VU
University Medical center, Amsterdam, Noord-Holland,
Netherlands
There is no reliable imaging marker for the
differentiation between Alzheimers Disease (AD) and
behavioral variant Frontotemporal Dementia (bvFTD).
Involvement of fronto-striatal circuits in bvFTD
suggests that basal nuclei may help in distinguishing
these two types of dementia. Investigation of 7
subcortical structures with the FIRST algorithm in
patients with AD, bvFTD and controls revealed that
hippocampal and amygdala volume were reduced in both
types of dementia to a similar extent. However, volumes
of caudate nucleus, nucleus accumbens and globus
pallidus were smaller in bvFTD than in AD, providing
evidence for a potential marker for the discrimination
between bvFTD and AD.
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