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Abstract #4738

More severe atrophy of basal nuclei in behavioral variant Frontotemporal Dementia compared to Alzheimers disease

Christiane Mller 1 , Nikki Dieleman 2 , Wiesje van der Flier 1,3 , Adriaan Versteeg 4 , Yolande Pijnenburg 1 , Philip Scheltens 1 , Frederik Barkhof 4 , and Hugo Vrenken 4,5

1 Neurology / Alzheimercenter, Neuroscience Campus Amsterdam, VU University Medical center, Amsterdam, Noord-Holland, Netherlands, 2 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 3 Epidemiology & Biostatistics, Neuroscience Campus Amsterdam, VU University Medical center, Amsterdam, Noord-Holland, Netherlands, 4 Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical center, Amsterdam, Noord-Holland, Netherlands, 5 Physics & Medical Technology, Neuroscience Campus Amsterdam, VU University Medical center, Amsterdam, Noord-Holland, Netherlands

There is no reliable imaging marker for the differentiation between Alzheimers Disease (AD) and behavioral variant Frontotemporal Dementia (bvFTD). Involvement of fronto-striatal circuits in bvFTD suggests that basal nuclei may help in distinguishing these two types of dementia. Investigation of 7 subcortical structures with the FIRST algorithm in patients with AD, bvFTD and controls revealed that hippocampal and amygdala volume were reduced in both types of dementia to a similar extent. However, volumes of caudate nucleus, nucleus accumbens and globus pallidus were smaller in bvFTD than in AD, providing evidence for a potential marker for the discrimination between bvFTD and AD.

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