Abstract #4739
ASSESSING BRAIN SYSTEM DYSFUNCTION IN AMNESIC MILD COGNITVE IMPAIRMENT THROUGH MRI-BASED CONNECTOMICS
Federica Agosta 1 , Elisa Canu 1 , Sebastiano Galantucci 1 , Alessandro Meani 1 , Giuseppe Magnani 2 , Alessandra Marcone 3 , Andrea Falini 4 , Giancarlo Comi 2 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Department of Neurology, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
3
Department
of Clinical Neurosciences, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
4
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Our study showed that global functional network
organization is spared in the aMCI patients, except for
the higher hierarchy likely reflecting a high
sub-modular decomposition of the functional networks. On
the contrary, local functional network organization is
altered in aMCI patients in critical regions known to be
hit by Alzheimer's disease. The graph analysis approach
is promising for understanding the pathophysiology of
the functional impairment of aMCI patients and
convertion to dementia. Longitudinal studies are needed
to further investigate the clinical meaning of the
presenting data.
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