The relationship of neuroimaging measures to dementia status and cognition in older adults with Down Syndrome

The current work investigates the relationship between neuroanatomical and proton magnetic resonance spectroscopy (1H-MRS) and measures of cognitive functioning and dementia in individuals with DS. 15 adults with Down Syndrome underwent 1H-MRS scanning at the left dorsal lateral prefrontal cortex (DLPFC). DLPFC choline was related to both measures of cognition and dementia. Cortical and subcortical grey matter volumes were related to age, and white matter and ventricular volumes were related to dementia measures. These results highlight the need for longitudinal studies of this population, to clarify the relationship between imaging measures, baseline cognitive ability, and dementia.

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