Abstract #4740
The relationship of neuroimaging measures to dementia status and cognition in older adults with Down Syndrome
Katherine A Koenig 1 and Pallab Bhattacharyya 1
1
Imaging Sciences, The Cleveland Clinic,
Cleveland, OH, United States
The current work investigates the relationship between
neuroanatomical and proton magnetic resonance
spectroscopy (1H-MRS) and measures of cognitive
functioning and dementia in individuals with DS. 15
adults with Down Syndrome underwent 1H-MRS scanning at
the left dorsal lateral prefrontal cortex (DLPFC). DLPFC
choline was related to both measures of cognition and
dementia. Cortical and subcortical grey matter volumes
were related to age, and white matter and ventricular
volumes were related to dementia measures. These results
highlight the need for longitudinal studies of this
population, to clarify the relationship between imaging
measures, baseline cognitive ability, and dementia.
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