Abstract #4741
Regional White Matter disruption within the Corpus Callosum in patients with Mild Cognitive Impairment Single and Multiple domain
Elena Makovac 1 , Barbara Span 1 , Laura Serra 1 , Giovanni Giulietti 1 , Mario Torso 1 , Mara Cercignani 1,2 , Carlo Caltagirone 3,4 , and Marco Bozzali 1
1
Neuroimaging Laboratory, IRCCS Santa Lucia
Foundation, Rome, Italy,
2
Clinical
Imaging Sciences Centre, Brighton and Sussex Medical
School, United Kingdom,
3
Department
of Neuroscience, University of Rome Tor Vergata, Rome,
Italy,
4
Department
of Clinical and Behavioural Neurology, IRCCS Santa Lucia
Foundation, Rome, Italy
Two main clinical subtypes of amnestic MCI has been
described, single-domain and multiple-domain aMCI In the
present study we examined the Corpus Callosum (CC) by
applying DTI-based tractography in SDamci and MDamci.
Using a vixel-based approach, we were able to delineate
a precise direction of WM damage inside the CC, starting
from the Splenium in SDamci and proceeding toward the
Genu in the MDamci, and eventually declining in a
general CC WM damage in the final AD stage. These
findings clarify some relevant aspects of AD
pathophysiology and provide information of potential
prognostic value for disease monitoring.
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