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Abstract #4750

Translational implementation of non-invasive Magnetic Resonance brain oxygen mapping in acute (72 hours) ischemic stroke patients

Florence Colliez 1 , Julie Magat 1 , Marta M Safronova 2 , Bndicte F Jordan 1 , Bernard Gallez 1 , and Thierry Duprez 3

1 Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium, 2 Service de Radiologie, Cliniques universitaires Saint-Luc, Brussels, Belgium, 3 Department of Radiology and Medical Imaging, Cliniques universitaires Saint-Luc, Brussels, Belgium

Mapping brain oxygenation is a key-challenge in the clinical work-up of many cerebral disorders. Measurements of proton T1 relaxation induced by paramagnetic molecular oxygen have previously demonstrated capability to monitor changes in tissue oxygenation. The MOBILE (Mapping of Oxygen by Imaging Lipid relaxation Enhancement) sequence increases the sensitivity of this measurement by selectively calculating the spin-lattice (T1) relaxation of lipids after suppressing water signal. We hereby investigated in a translational proof of concept way whether MOBILE enabled detection of brain oxygen deprivation in the clinical setting of ischemic acute ischemic (72 hours) stroke patients.

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