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Abstract #4751

Characterization of a 60-minute MCAO using immunohistochemical evaluation in conjunction with MRI

Lora Talley Watts 1 , Qiang Shen 1 , and Timothy Duong 1

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

This study examined the expression of an early and late marker of the apoptotic cascade associated with perfusion and diffusion abnormality at 2 and 24 hours following a 60 minute MCAO in rats. Quantitative correlations of apoptotic expression were made with ADC and CBF measures. We found a strong correlation of ADC and CBF values with molecular markers of apoptosis and cell death. The finding provide molecular underpinnings of quantitative prediction of ischemic fate and functional reorganization based on acute MRI data.

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