Meeting Banner
Abstract #4754

Transsynaptic effect on degeneration of callosal motor fibers in patients with stroke using diffusion spectrum imaging

Chia-Lin Koh 1 , Pei-Fang Tang 2 , Hsiu-I Chen 3 , Ching-Lin Hsieh 1 , and Wen-Yih Isaac Tseng 4,5

1 School of Occupational Therapy, National Taiwan University, Taipei, Taiwan, 2 School and Graduate Institute of Physical Therapy, National Taiwan University, Taipei, Taiwan, 3 Department of Physical Therapy, Hung-Kuang University, Taichung, Taiwan, 4 Center for Optoelectronic Biomedicine, National Taiwan University, Taipei, Taiwan, 5 Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan

The callosal motor fibers (CMF) were found to be degenerated in chronic stroke patients whose lesions involved corticospinal tract (CST) at the level below corpus callosum. Our study results supported that the degeneration of CMF was due to retrograde transsynaptic degeneration effect from CST degeneration. Furthermore, we found that the integrity of CMF contributes to upper extremity motor impairment severity in addition to CST integrity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here