Abstract #4754
Transsynaptic effect on degeneration of callosal motor fibers in patients with stroke using diffusion spectrum imaging
Chia-Lin Koh 1 , Pei-Fang Tang 2 , Hsiu-I Chen 3 , Ching-Lin Hsieh 1 , and Wen-Yih Isaac Tseng 4,5
1
School of Occupational Therapy, National
Taiwan University, Taipei, Taiwan,
2
School
and Graduate Institute of Physical Therapy, National
Taiwan University, Taipei, Taiwan,
3
Department
of Physical Therapy, Hung-Kuang University, Taichung,
Taiwan,
4
Center
for Optoelectronic Biomedicine, National Taiwan
University, Taipei, Taiwan,
5
Graduate
Institute of Brain and Mind Sciences, National Taiwan
University, Taipei, Taiwan
The callosal motor fibers (CMF) were found to be
degenerated in chronic stroke patients whose lesions
involved corticospinal tract (CST) at the level below
corpus callosum. Our study results supported that the
degeneration of CMF was due to retrograde transsynaptic
degeneration effect from CST degeneration. Furthermore,
we found that the integrity of CMF contributes to upper
extremity motor impairment severity in addition to CST
integrity.
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