Cerebral Vascular Reactivity Assessment Using the SR-T 1 Method in Normal and MCAO Rat Brain

Cerebral vascular reactivity (CVR) is an important physiologic property of assessing brain arteries response to vasoactive challenge and it is of great value of studying many cerebrovascular diseases, such as arterial stenosis, ischemic stroke and hypertension. CVR could be evaluated by positron emission tomography (PET), single-photon emission computed tomography (SPECT), transcranail Doppler (TCD) ultrasonography as well as magnetic resonance imaging (MRI) approaches, such as blood-oxygen-level dependent (BOLD) response, arterial spin labeling (ASL) based cerebral blood flow (CBF) calculation. In the present study, we demonstrate that the saturation-recover T1 (SR-T1) imaging method is sensitive and reliable to evaluate CVR by comparing it with the CASL based CBF method. Data show that the spatial pattern of CVR images generated with these two techniques is very similar in both normal and MCAO rat brain. Moreover, there is an excellent agreement of percentage CVR change imaged with these two techniques although their absolute scales are different. Therefore, the SR-T1 method provides a simple and reliable way of evaluating CVR in addition to measure parametric tissue property of T1/R1, CBF change and BOLD simultaneously.

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