Abstract #4756
fMRI of Cerebrovascular Reserve in Patients with Severe Intracranial Arterial Stenosis
Alexandre Krainik 1,2 , Arnaud Attye 1 , Naila Boudiaf 3 , Johan Pietras 4 , Thomas Perret 2 , Irene Tropres 3 , Florence Tahon 1 , and Olivier Detante 2,5
1
Neuroradiology and MRI, University Hospital
of Grenoble, Grenoble, France,
2
U836
Grenoble Institute of Neurosciences, INSERM, Grenoble,
France,
3
IRMaGe facility, University Joseph
Fourier, France,
4
IRMaGe
facility, University Joseph Fourier, Grenoble, France,
5
Neurology,
University Hospital of Grenoble, Grenoble, France
Management of patients with Severe Intracranial Arterial
Stenosis (SIAS) at risk of stroke events recurrence
remains controversial. A better characterization of
these patients might be helpful to define therapeutic
strategy. BOLD fMRI to hypercapnic challenge has been
proposed to identify impaired cerebrovascular reserve (CVR
BOLD fMRI). We conducted a prospective study in 21
patients referred for a SIAS to estimate CVR BOLD fMRI,
and compared their data a 100 volunteers dataset. Nine
patients out of 21 had significantly impaired CVR. Thus,
CVR BOLD fMRI could be helpful to better select patients
with SIAS for more invasive treatment.
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