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Abstract #4764

Tract-based assessment of the subcortical motor network plasticity after stroke

Silvia Obertino 1 , Ying-Chia Lin 2 , Alessandro Daducci 3 , Jean-Philippe Thiran 3 , Reto Meuli 4 , Gunnar Krueger 5 , Cristina Granziera 4 , and Gloria Menegaz 1

1 Computer Science, University of Verona, Verona, Select, Italy, 2 Computer Science, University of Verona, Italy, 3 Swiss Federal Institute of Technology (EPFL), Switzerland, 4 CHUV, Lausanne, Switzerland, 5 Siemens, Switzerland

This study aimed at investigating myelin and axonal plasticity in the subcortical motor networks (SC-MN) contralateral to stroke by applying diffusion spectrum (DSI) and magnetization transfer (MT) imaging. Ten patients and ten HC underwent DSI scans. Generalized Fractional Anisotropy (GFA) was derived from DSI scans and Magnetization transfer ratio (MTR) values were calculated as percent of the ratio (MT-M0)/M0 for each fiber. Both histogram features (mean, variance, skewness, kurtosys, peak hight, peak position) and measures of histogram distances were used for between group comparisons. Results suggest both short term (1 month) and mid term (6 months) axonal and myelin plasticity in the uninjured cortico-subcortical motor circuits.

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