Abstract #4765
Quantitative Study of Longitudinal Relaxation Rate Change in the Transient MCAO Rat Brain
Xiao Wang 1 , Afshin A Divani 2 , Xiao-Hong Zhu 1 , Jessica Nordberg 2 , Julian Tokarev 2 , Yi Zhang 1 , and Wei Chen 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota Medical
School, Minneapolis, Minnesota, United States,
2
Neurology,
University of Minnesota, Minnesota, United States
The longitudinal relaxation rate (time) R1 (T1) is a
crucial physical property which could guide the choice
of imaging parameters and its alteration of tissue is
also closely related to the underlying pathology of
variety of diseases. This study aims to quantitatively
investigate the R1 change of the rat brain tissue
subsequent to the middle cerebral artery occlusion (MCAO)
on day 1 and day 7 after a 1-hour occlusion, and to
examine CBF contribution to the brain tissue R1
alteration. The results show that the R1 in the varied
lesion area decreases about 6-25% of its contralateral
control and the R1 decrease is mainly dominated by the
brain tissue property alteration. In addition, R1 shows
statistic difference among varied lesion region while no
statistic significant difference is found among baseline
CBF on both day 1 and day 7 of post-occlusion,
indicating that the R1 images are potentially more
sensitive to the extent of lesion than CBF images. The
quantified T1 (or R1) image is an important imaging
modality and should provide a noninvasive, sensitive and
reliable way to help determining the tissue damage
caused by ischemic cerebrovascular diseases.
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