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Abstract #4771

Time dependent treatment outcomes of NBO in experimental ischemic stroke

Yash Vardhan Tiwari 1 , Pavel Rodriguez 1 , Yuhao Sun 1 , Zhao Jiang 1 , Fang Du 1 , Qiang Shen 1 , Wei Li 1 , and Timothy Q Duong 1

1 Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States

Previous studies have shown normobaric hyperoxia (NBO) to be effective in extending treatment time window in animal model of transient cerebral ischemia. However, both positive and negative effects of NBO treatment have been reported. As such, it is highly likely that the efficacy of NBO treatment in the early phase of ischemic insult is critically dependent on the treatment duration. To test this hypothesis, we evaluated the effects of varying treatment duration for NBO administration (25 and 150 min) on the 60-min MCAO model of stroke, longitudinally and noninvasively using quantitative MRI. We found that in early phase of acute experimental stroke the treatment outcome of NBO varies in a time dependent manner.

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