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Abstract #4772

Brain imaging results identify structural and vascular abnormalities in type 2 diabetic adults compared to hypertensive controls

Ekaterina Tchistiakova 1,2 , Carol E. Greenwood 3,4 , Nicole D. Anderson 3,5 , and Bradley J. MacIntosh 1,2

1 Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2 Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada, 3 Rotman Research Institute, Baycrest, Toronto, ON, Canada, 4 Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada, 5 Department of Medicine (Psychiatry), University of Toronto, Toronto, ON, Canada

Recent studies suggest that the negative effects of type 2 diabetes (T2DM) on the brain can result in increased risk of cognitive decline and dementia. It is still unclear, however, if T2DM effects exceed those seen in co-occurring comorbidities, in particular hypertension (HTN). In this study imaging metrics were used to compare brain structure and vascular integrity between individuals with T2DM and HTN and hypertensive controls. Our results demonstrate regional decreases in vascular reactivity and tissue volume (i.e. cortical thinning) in the right visual processing regions in individuals with T2DM and HTN compared to HTN alone.

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