Abstract #4779
Evaluation of a multiparametric qBOLD (mqBOLD) and cerebrovascular reserve in patients with severe intracranial arterial stenosis : a comparison study
Julien Bouvier 1,2 , Olivier Detante 1,3 , Florence Tahon 4 , Arnaud Attye 4 , Thomas Perret 1 , David Chechin 2 , Irene Tropres 1,5 , Sylvie Grand 4,6 , Emmanuel L Barbier 1,6 , and Alexandre Krainik 1,4
1
U836, INSERM, Grenoble, France, France,
2
Philips
Healthcare, Suresnes, France, France,
3
Department
of neurology, Joseph Fourier University, France, France,
4
Department
of neuroradiology and MRI, CHU de Grenoble, France,
France,
5
IRMaGe
facility, Joseph Fourier University, France, France,
6
Grenoble
Institute of Neurosciences, Joseph Fourier University,
France, France
To identify hemodynamic alteration related to
steno-occlusive disease, functional MRI of
cerebrovascular reserve (CVR fMRI) to hypercapnia has
been proposed. A decreased vascular reserve downstream a
severe intracranial arterial stenosis (SIAS) was
associated with increased apparent diffusion
coefficient, suggesting a chronic low-grade ischemia.
However, relationships between hemodynamic disorder and
metabolism has not been shown using MRI, yet. In such
patients, these abnormalities may further motivate
endovascular stenting. The aim of this study was to
determine the relationships between tissular oxygen
metabolism assessed with a multiparametric qBOLD
(mqBOLD) approach with basal and functional changes of
perfusion in patients with SIAS.
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