Abstract #4780
Association of Embolic Stroke Territory with Aortic Arch Retrograde Flow in patients with Cryptogenic Stroke
Edouard Michel Semaan 1 , Shyam Prabhakaran 2 , Kameswari Maganti 3 , Pim van Ooij 1 , Zoran Stankovic 1 , Alex Barker 1 , James Carr 1 , Michael Markl 1,4 , and Jeremy Collins 1
1
Radiology Department, Feinberg School of
Medicine Northwestern University, Chicago, Illinois,
United States,
2
Neurology
Department, Feinberg School of Medicine Northwestern
University, Chicago, Illinois, United States,
3
Cardiology
Department, Feinberg School of Medicine Northwestern
University, Chicago, Illinois, United States,
4
Department
of Biomedical Engineering, McCormick School of
Engineering, Illinois, United States
Cryptogenic stroke accounts for 20-25% of embolic
ischemic strokes. Several studies have suggested an
association between descending aortic plaque and stroke.
The purpose of this study was to assess retrograde
diastolic flow at 4D flow MRI from the descending
thoracic aorta into the great vessels in patients with
cryptogenic stroke, as a potential stroke etiology. The
prevalence of retrograde diastolic flow into the great
vessels was 57%, and correlated with stroke location in
65% of subjects, providing a potential etiology for
embolic stroke. Integrating 4D flow MRI into the
cryptogenic stroke evaluation may enable therapies to
prevent recurrent atheroembolism.
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