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Abstract #4782

The application of functional challenge tasks in Moyamoya patients

Chou-Ming Cheng 1,2 , Jin-Jie Hung 1 , Hsiao-Wen Chung 3 , Hung Sheng Che 4 , Muh-Lii Liang 5 , Jen-Chuen Hsieh 1 , Shing-Jong Lin 1 , and Tzu-Chen Yeh 4

1 Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan, 2 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, Syrian Arab Republic, 3 Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, Taiwan, 4 Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan, 5 Neurosurgery Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan

Moyamoya disease is characterized by Moyamoya vessels near the stenosis regions induced by progressive stenosis of the internal carotid artery, cerebral artery. CVR and OEF are critical indicators of the severity in Moyamoya disease. In this research, blood oxygenation level dependence (BOLD) functional Magnetic Resonance Imaging (fMRI) of carbogen inhalation and hand grasping are adapted as challenge tasks to probe CVR and OEF in Moyamoya disease.

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