Abstract #4791
Methylene blue treatment delays the progression of ischemic penumbra into infarct
Pavel Rodriguez 1 , Jiang Zhao 2 , Shiliang Huang 2 , Qiang Shen 2 , and Timothy Q. Duong 2
1
Department of Radiology, University of Texas
Health Science Center at San Antonio, San Antonio,
Texas, United States,
2
Research
Imaging Institute, University of Texas Health Science
Center at San Antonio, San Antonio, Texas, United States
Methylene blue (MB) has unique energy enhancing and
antioxidant properties and has recently been shown to
reduce neurobehavioral impairment in animal models of
Parkinson's and Alzheimers Diseases. We recently showed
that MB has significant effect on hemodynamics,
metabolic activity, and evoked responses in vivo using
MRI. The goal of this study was to evaluate the
neuroprotective effect of MB treatment in ischemic
stroke. We tested the hypothesis that MB treatment
delays infarct growth in a permanent stroke in rats.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
