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Abstract #4791

Methylene blue treatment delays the progression of ischemic penumbra into infarct

Pavel Rodriguez 1 , Jiang Zhao 2 , Shiliang Huang 2 , Qiang Shen 2 , and Timothy Q. Duong 2

1 Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States, 2 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Methylene blue (MB) has unique energy enhancing and antioxidant properties and has recently been shown to reduce neurobehavioral impairment in animal models of Parkinson's and Alzheimers Diseases. We recently showed that MB has significant effect on hemodynamics, metabolic activity, and evoked responses in vivo using MRI. The goal of this study was to evaluate the neuroprotective effect of MB treatment in ischemic stroke. We tested the hypothesis that MB treatment delays infarct growth in a permanent stroke in rats.

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