Optimization of Magnetization Prepared Rapid Gradient Echo (MP-RAGE) at 7T
Manojkumar Saranathan 1 , Thomas Tourdias 1 , May Han 2 , and Brian K Rutt 1
Department of Radiology, Stanford
University, Stanford, CA, United States,
of Neurology and Neurological Sciences, Stanford
University, Stanford, CA, United States
The purpose of this work was to optimize MP-RAGE imaging
at 7T. Two regimes- a conventional cerebral spinal fluid
nulled (CSFn) and a white-matter nulled (WMn) MP-RAGE
for imaging cortical lesions and thalamus-were optimized
for scan time, SNR and contrast efficiency. The effect
of α and TR on image blurring was modeled and validated.
A novel 2D-centric radial fanbeam (RFB) k-space
segmentation scheme was used for reducing scan times.
Finally, healthy human subjects and patients with
multiple sclerosis (MS) were scanned at 7T to
demonstrate novel lesion detectability.
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