Meeting Banner
Abstract #0004

Whole-brain in-vivo measurements of the axonal g-ratio in a group of 19 healthy volunteers

Siawoosh Mohammadi 1 , Daniel Carey 2 , Fred Dick 3 , Joern Diedrichsen 4 , Martina F. Callaghan 5 , Marty Sereno 2 , Marco Reisert 6 , and Nikolaus Weiskopf 5

1 Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 2 Birkbeck/UCL Centre for NeuroImaging, London, London, United Kingdom, 3 Birkbeck/UCL Centre for NeuroImaging, London, United Kingdom, 4 UCL Institute of Cognitive Neurology, London, United Kingdom, 5 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, 6 University of Freiburg Medical Center, Freiburg, Germany

Quantitative MRI aims to generate measures that are specific to particular aspects of tissue microstructure. The g-ratio, quantifying the ratio between the inner and outer diameters of a fibre, has been shown to be related to the conductance velocity and exhibit plasticity in functional stimulation experiments. Here we present in vivo g-ratio measures and population statistics from 19 volunteers. The g-ratio was calculated by combining magnetisation saturation maps and high angular resolution diffusion imaging (HARDI) data. The MRI-based in vivo g-ratio measures are in good agreement with histological findings and have the potential to become an important neuroimaging biomarker.

This abstract and the presentation materials are available to members only; a login is required.

Join Here