Abstract #0004
Whole-brain in-vivo measurements of the axonal g-ratio in a group of 19 healthy volunteers
Siawoosh Mohammadi 1 , Daniel Carey 2 , Fred Dick 3 , Joern Diedrichsen 4 , Martina F. Callaghan 5 , Marty Sereno 2 , Marco Reisert 6 , and Nikolaus Weiskopf 5
1
Department of Systems Neuroscience,
University Medical Center Hamburg-Eppendorf, Hamburg,
Hamburg, Germany,
2
Birkbeck/UCL
Centre for NeuroImaging, London, London, United Kingdom,
3
Birkbeck/UCL
Centre for NeuroImaging, London, United Kingdom,
4
UCL
Institute of Cognitive Neurology, London, United
Kingdom,
5
Wellcome Trust Centre for
Neuroimaging, UCL Institute of Neurology, London, United
Kingdom,
6
University
of Freiburg Medical Center, Freiburg, Germany
Quantitative MRI aims to generate measures that are
specific to particular aspects of tissue microstructure.
The g-ratio, quantifying the ratio between the inner and
outer diameters of a fibre, has been shown to be related
to the conductance velocity and exhibit plasticity in
functional stimulation experiments. Here we present in
vivo g-ratio measures and population statistics from 19
volunteers. The g-ratio was calculated by combining
magnetisation saturation maps and high angular
resolution diffusion imaging (HARDI) data. The MRI-based
in vivo g-ratio measures are in good agreement with
histological findings and have the potential to become
an important neuroimaging biomarker.
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