Meeting Banner
Abstract #0005

In vivo mapping of myelin g-ratio in the human spinal cord

T. Duval 1 , S. Lvy 1 , N. Stikov 1,2 , A. Mezer 3 , T. Witzel 4 , B. Keil 4 , V. Smith 4 , L. L. Wald 4 , E. Klawiter 4 , and J. Cohen-Adad 1,5

1 Institute of Biomedical Engineering, Polytechnique Montral, Montral, Qubec, Canada, 2 Montreal Neuronal Institute, McGill University, Montral, Qubec, Canada, 3 Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University, Jerusalem, Israel, 4 A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States, 5 Functional Neuroimaging Unit, CRIUGM, Universit de Montral, Montral, Qubec, Canada

The myelin g-ratio is the ratio of the inner to the outer diameter of the myelin sheath. As such, it provides a measure of the myelin thickness that complements axon morphology, with high specificity towards demyelination. We demonstrate for the first time in vivo mapping of myelin g-ratio in the human spinal cord using 300 mT/m gradient system. Average g-ratio was 0.74, which is consistent with the reported optimal g-ratio of 0.70 in from histology work. The proposed method is feasible in a clinically-acceptable time and could be useful for assessing demyelination in multiple sclerosis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here