The role of myelin geometry on magnetic susceptibility-driven frequency shifts: toward realistic geometries

This work investigates the role that the geometry of myelin has on susceptibility driven frequency shifts in white matter. Packed axons, representative of axon bundles, capture important aspects of tissue microstructure. Here we demonstrate via simulation that axonal shape has a nontrivial effect on the underlying distribution of proton frequencies and on the free induction decay signal magnitude and phase. To bridge simulation with physical reality, we derive a structural template from electron microscopy in excised white matter, which is then used to forward calculate the frequency distribution and signal.

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