Understanding Signal Sources of MT Asymmetry and Inhomogeneous MT for Imaging Myelination

As methods for imaging myelination, we investigated signal sources of MT asymmetry (MTA) and inhomogeneous MT (IHMT), both of which utilize asymmetric aspects of MT spectrum. The phantom study showed similar specificity of MTA and IHMT to myelination. Under the same average power and total saturation duration, however, IHMT was independent of asymmetric shift in saturation offset frequencies but dependent on duration of each saturation RF pulse, whereas MTA showed characteristics opposite to IHMT. Although both IHMT and MTA may be useful for myelin imaging, further studies are necessary to understand the signal sources and sensitivity/specificity of MTA and IHMT.

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