Frequency difference mapping for measurement of white matter microstructure

Frequency difference mapping (FDM) is a novel technique that takes advantage of the non-linear temporal evolution of the phase in gradient echo sequences to obtain images that carry information about white matter (WM) microstructure. In contrast to other phase-based approaches for probing WM properties such as QSM and STI, FDM can yield local contrast that is sensitive to microstructure without requiring sophisticated filtering of phase images. Here a straightforward implementation of FDM is presented. The application of this approach to the measurement of the variation of microstructure across the corpus callosum in a study of 10 subjects is also described.

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