Modelling the effect of white matter microstructure on gradient echo signal evolution

The evolution of the magnitude and phase of gradient echo (GE) signals is sensitive to white matter (WM) microstructure. This effect has been characterised by using a three-pool model of WM, comprised of axonal, myelin and external compartments. This work compares the magnitude and phase signals produced using triple-exponential and geometric single/multiple-fibre models, showing that the triple-exponential model can be improved in the static dephasing regime by adding in terms which approximately account for frequency variation in the myelin and external compartments. We also demonstrate the effects of including a range of fibre sizes and diffusion in a multiple-fibre model.

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