Signatures of microstructure in conventional gradient and spin echo signals

Diffusion imaging has long been the method of choice for probing tissue microstructure. We show that signatures of microstructure are also present in the signals from conventional gradient and spin echo sequences. Preliminary results from phantoms containing polystyrene beads of known diameter demonstrate that the logarithms of the signals from both multiple gradient echo and single spin echo sequences decrease nonlinearly with TE, in agreement with theory. Numerical fits provide estimates of bead diameter and magnetic susceptibility in rough agreement with expected values. This has implications for studies of tissue microstructure and for interpretation of gradient and spin echo signals.

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