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Abstract #0015

Dependance of the apparent T 1 on Magetization Transfer

Peter van Gelderen 1 , Xu Jiang 1 , and Jeff H Duyn 1

1 AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

In human brain, T1-contrast is strongly affected by bound protons in myelin, whose rapid T1-relaxation influences the more mobile water protons through magnetization transfer. MT also affects the apparent, instantaneous T1-relaxation in inversion recovery (IR) experiments due to magnetization differences between bound and mobile protons generated by the inversion pulse. The amplitude and timescale of this effect was investigated comparing the IR following inversions at different B1-levels, which differentially saturate the bound proton magnetization. The white-matter IR resembled a two- exponential decay, with the more rapid decay having a 90ms time constant and a B1-dependent amplitude ranging from 12-19%.

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