Abstract #0016
Towards an Optimized and Standardized Amide Proton Transfer (APT) MRI Sequence and Protocol for Clinical Applications
Hye-Young Heo 1 , Yi Zhang 1 , Jochen Keupp 2 , Yansong Zhao 3 , Michael Schar 1 , Dong-Hoon Lee 1 , Peter C.M van Zijl 1,4 , and Jinyuan Zhou 1,4
1
Russell H Morgan Department of Radiology and
Radiological Science, Johns Hopkins University,
Baltimore, Maryland, United States,
2
Philips
Research, Hamburg, Germany,
3
Philips
Healthcare, Cleveland, Ohio, United States,
4
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States
APT-weighted imaging is a novel chemical exchange
saturation transfer (CEST)-based MRI modality that gives
contrast due to endogenous cytosolic protein and peptide
content, as well as tissue pH,
in
vivo
. In this abstract, several APTw-MRI sequences
that are feasible for clinical applications were
compared on phantoms, healthy subjects, and a patient
with glioblastoma. Time-interleaved pTX sequences,
particularly using the TSE acquisition, can maximize
SNRs and APT-MRI effects on clinical scanners by
avoiding RF amplifier limitations to the saturation
pulses.
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