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Abstract #0016

Towards an Optimized and Standardized Amide Proton Transfer (APT) MRI Sequence and Protocol for Clinical Applications

Hye-Young Heo 1 , Yi Zhang 1 , Jochen Keupp 2 , Yansong Zhao 3 , Michael Schar 1 , Dong-Hoon Lee 1 , Peter C.M van Zijl 1,4 , and Jinyuan Zhou 1,4

1 Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States, 2 Philips Research, Hamburg, Germany, 3 Philips Healthcare, Cleveland, Ohio, United States, 4 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

APT-weighted imaging is a novel chemical exchange saturation transfer (CEST)-based MRI modality that gives contrast due to endogenous cytosolic protein and peptide content, as well as tissue pH, in vivo . In this abstract, several APTw-MRI sequences that are feasible for clinical applications were compared on phantoms, healthy subjects, and a patient with glioblastoma. Time-interleaved pTX sequences, particularly using the TSE acquisition, can maximize SNRs and APT-MRI effects on clinical scanners by avoiding RF amplifier limitations to the saturation pulses.

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