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Abstract #0017

Can Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer (NOE-CEST) Offer a New Insight in Acute Stroke Diagnosis?

Yee Kai Tee 1 , George WJ Harston 2 , Nicholas Blockley 3 , Robert Frost 3 , Thomas W Okell 3 , Sivarajan Thandeswaran 2 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 5 , and Michael Chappell 5

1 Department of Mechatronics and BioMedical Engineering, Universiti Tunku Abdul Rahman, KL, KL, Malaysia, 2 Acute Stroke Programme, Radcliffe Department of Medicine, Oxford University, Oxfordshire, United Kingdom, 3 Oxford Centre of Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, Oxford University, Oxfordshire, United Kingdom, 4 Department of Neuroradiology, Oxford University Hospitals NHS Trust, Oxfordshire, United Kingdom, 5 Department of Engineering Science, Institute of Biomedical Engineering, Oxford University, Oxfordshire, United Kingdom

Chemical exchange saturation transfer (CEST) data in acute stroke patients (within 6 hours of onset) were acquired to compare nuclear Overhauser enhancement mediated CEST (NOE-CEST) with apparent diffusion coefficient (ADC) and pH-weighted imaging using amide proton transfer (APT). This work is the first demonstration of NOE-CEST in acute human stroke. NOE-CEST provides a unique contrast compared to ADC and pH-weighted imaging in tissue that progresses to infarction, suggesting that NOE-CEST may offer a new insight in acute stroke management.

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