Abstract #0019
Novel Biomarkers of Mitochondrial Function: the Mitochondrial Index and the Crossing Point of Glucose and Oxygen Consumption Curves obtained by Dynamic Deuterium Magnetic Resonance
Gheorghe D Mateescu 1 , Chris A Flask 2,3 , Allen Ye 4 , Bernadette Erokwu 5 , Michael Twieg 6 , Karishma Gupta 5 , and Mark Griswold 3,5
1
Chemistry, Case Western Reserve University,
Cleveland, OH, United States,
2
Biomedical
Engineering, Case Western Reserve University, Cleveland,
OH, United States,
3
Case
Western Reserve University, OH, United States,
4
Bioengineering,
University of Indiana at Chicago, IN, United States,
5
Radiology,
Case Western Reserve University, OH, United States,
6
Biomedical
Engineering, Case Western Reserve University, OH, United
States
Preliminary results on mice demonstrate that it is
possible to simultaneously measure, in vivo, the glucose
and oxygen consumption in mitochondria by Dynamic
Deuterium MR, following administration of deuteriated
glucose. Novel biomarkers for the bio-energetic output
of cells in organs and tissues the Mitochondrial Index
and the Crossing Point of the consumption curves are
proposed; their association with the state of health of
a live organism and the transferability of the method to
the clinic is discussed.
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