Abstract #0020
Chronic Diabetes Reprograms Carbohydrate Metabolism in the Heart and Kidney: A Hyperpolarised 13C Magnetic Resonance Spectroscopy Study
Marie A Schroeder 1,2 , Albert P Chen 2,3 , Albert Tsui 4 , M Mitchell 4 , Jean-Francois Desjardins 4 , Golam Kabir 4 , Charles H Cunningham 2 , and Kim A Connelly 2,4
1
Singapore Bioimaging Consortium, Agency for
Science, Technology and Research, Singapore, Singapore,
Singapore,
2
Schulich
Heart Research Program, Sunnybrook Health Science
Centre, Toronto, ON, Canada,
3
GE-Healthcare,
Toronto, ON, Canada,
4
Keenan
Research Centre in the Li Ka Shing Knowledge Institute,
St. Michaels Hospital, Toronto, ON, Canada
We tested the hypothesis that chronic diabetes would
cause clinical signs and symptoms of heart failure with
preserved ejection fraction (HFpEF). By following
hyperpolarised [1-13C]pyruvate metabolism in heart and
kidneys using MRS, we defined how chronic diabetes
reprogrammed carbohydrate utilisation. Diabetic rats
showed evidence of HFpEF via echocardiography, pressure
volume loops and histology, including preserved ejection
fraction, diastolic dysfunction, fibrosis, pulmonary
congestion, and nephropathy. Hyperpolarised 13C MRS
revealed a shift towards lactate production in the heart
and kidneys of diabetic rats, which may indicate
increased gluconeogenesis and inflammation. Further
study of chronic diabetic cardiomyopathy will be
important in developing the first treatments for HFpEF.
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