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Abstract #0020

Chronic Diabetes Reprograms Carbohydrate Metabolism in the Heart and Kidney: A Hyperpolarised 13C Magnetic Resonance Spectroscopy Study

Marie A Schroeder 1,2 , Albert P Chen 2,3 , Albert Tsui 4 , M Mitchell 4 , Jean-Francois Desjardins 4 , Golam Kabir 4 , Charles H Cunningham 2 , and Kim A Connelly 2,4

1 Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore, Singapore, 2 Schulich Heart Research Program, Sunnybrook Health Science Centre, Toronto, ON, Canada, 3 GE-Healthcare, Toronto, ON, Canada, 4 Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michaels Hospital, Toronto, ON, Canada

We tested the hypothesis that chronic diabetes would cause clinical signs and symptoms of heart failure with preserved ejection fraction (HFpEF). By following hyperpolarised [1-13C]pyruvate metabolism in heart and kidneys using MRS, we defined how chronic diabetes reprogrammed carbohydrate utilisation. Diabetic rats showed evidence of HFpEF via echocardiography, pressure volume loops and histology, including preserved ejection fraction, diastolic dysfunction, fibrosis, pulmonary congestion, and nephropathy. Hyperpolarised 13C MRS revealed a shift towards lactate production in the heart and kidneys of diabetic rats, which may indicate increased gluconeogenesis and inflammation. Further study of chronic diabetic cardiomyopathy will be important in developing the first treatments for HFpEF.

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