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Abstract #0021

Cardiac metabolic adaptations in diabetic mice protect the heart from pressure overload-induced failure: a combined in vivo MRI, MRS, and PET approach

Desiree Abdurrachim 1 , Miranda Nabben 1 , Verena Hoerr 2,3 , Michael T. Kuhlmann 4 , Philipp R. Bovenkamp 2 , Michael Schfers 4 , Klaas Nicolay 1 , Cornelius Faber 2 , Sven Hermann 4 , and Jeanine J. Prompers 1

1 Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Department of Clinical Radiology, University Hospital Mnster, Mnster, Germany, 3 Institute of Medical Microbiology, Jena University Hospital, Jena, Germany, 4 European Institute for Molecular Imaging, Mnster, Germany

Metabolic adaptations in the diabetic heart are proposed as an important contributor to the development of heart failure in diabetes patients. Using in vivo MRI, 1 H-MRS, 31 P-MRS, and PET, we investigated cardiac metabolic, energetic, and functional adaptations in non-diabetic and diabetic mice at baseline, and 1, 5, and 12 weeks after transverse aortic constriction (TAC)-induced pressure overload. While TAC resulted in progressive cardiac hypertrophy and dysfunction in non-diabetic mice, the effect of TAC on cardiac function in diabetic mice was much less prominent, which was associated with a blunted increase in cardiac glucose uptake and maintained cardiac energetics.

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