Abstract #0021
Cardiac metabolic adaptations in diabetic mice protect the heart from pressure overload-induced failure: a combined in vivo MRI, MRS, and PET approach
Desiree Abdurrachim 1 , Miranda Nabben 1 , Verena Hoerr 2,3 , Michael T. Kuhlmann 4 , Philipp R. Bovenkamp 2 , Michael Schfers 4 , Klaas Nicolay 1 , Cornelius Faber 2 , Sven Hermann 4 , and Jeanine J. Prompers 1
1
Biomedical NMR, Eindhoven University of
Technology, Eindhoven, Netherlands,
2
Department
of Clinical Radiology, University Hospital Mnster,
Mnster, Germany,
3
Institute
of Medical Microbiology, Jena University Hospital, Jena,
Germany,
4
European
Institute for Molecular Imaging, Mnster, Germany
Metabolic adaptations in the diabetic heart are proposed
as an important contributor to the development of heart
failure in diabetes patients. Using
in
vivo
MRI,
1
H-MRS,
31
P-MRS,
and PET, we investigated cardiac metabolic, energetic,
and functional adaptations in non-diabetic and diabetic
mice at baseline, and 1, 5, and 12 weeks after
transverse aortic constriction (TAC)-induced pressure
overload. While TAC resulted in progressive cardiac
hypertrophy and dysfunction in non-diabetic mice, the
effect of TAC on cardiac function in diabetic mice was
much less prominent, which was associated with a blunted
increase in cardiac glucose uptake and maintained
cardiac energetics.
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