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Abstract #0022

Alterations in Myofiber Architecture in Response to Left Ventricular Pressure Overload are Associated with the Upregulation of Genes Encoding for Cell Adhesion and Matrix Remodeling

Choukri Mekkaoui 1 , Howard H Chen 1 , Yin-Ching Iris Chen 1 , Marcel P Jackowski 2 , William J Kostis 1 , Timothy G Reese 1 , Ronglih Liao 3 , and David E Sosnovik 1

1 Harvard Medical School-Massachusetts General Hospital, Boston, MA, United States, 2 University of So Paulo, So Paulo, Brazil, 3 Brigham and Women's Hospital, Boston, MA, United States

Left ventricular hypertrophy (LVH) in response to pressure overload is initially adaptive but subsequently becomes maladaptive. We used diffusion tensor MRI (DTI) to determine how myofiber orientation changes in response to LVH in aortic-banded mice. In addition, we performed gene expression analysis to determine which gene pathways were associated with these changes. We show that LVH due to pressure overload is accompanied by a marked rightward shift in fiber orientation in the left ventricular free wall and the upregulation of genes encoding for cell-cell and cell-matrix adhesion.

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