Abstract #0047
Voxel-scale mapping of the mouse brain functional connectome
Adam Liska 1,2 , Alberto Galbusera 1 , Adam J. Schwarz 3 , and Alessandro Gozzi 1
1
Center for Neuroscience and Cognitive
Systems @ UniTn, Istituto Italiano di Tecnologia,
Rovereto, TN, Italy,
2
Center
for Mind/Brain Sciences, University of Trento, Rovereto,
TN, Italy,
3
Department
of Psychological and Brain Sciences, Indiana University,
Bloomington, IN, United States
Human brain imaging studies have revealed the presence
of functionally specialized sub-systems interlinked by
highly-connected hub nodes. However, the extent to
which a similar functional architecture exists in the
mouse brain remains to be fully elucidated. We have
computed voxel-scale whole-brain functional connectivity
maps to generate a comprehensive mouse brain functional
connectome. Consistent with human studies, we show that
mouse brain contains mutually-interconnected connector
hubs in several sub-regions of a default mode network,
and in well-known integrative cortical structures. Our
findings suggest the presence of
evolutionarily-conserved, mutually-interconnected
functional modules and cortical hubs as a fundamental
feature of the mammal brain.
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