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Abstract #0047

Voxel-scale mapping of the mouse brain functional connectome

Adam Liska 1,2 , Alberto Galbusera 1 , Adam J. Schwarz 3 , and Alessandro Gozzi 1

1 Center for Neuroscience and Cognitive Systems @ UniTn, Istituto Italiano di Tecnologia, Rovereto, TN, Italy, 2 Center for Mind/Brain Sciences, University of Trento, Rovereto, TN, Italy, 3 Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States

Human brain imaging studies have revealed the presence of functionally specialized sub-systems interlinked by highly-connected hub nodes. However, the extent to which a similar functional architecture exists in the mouse brain remains to be fully elucidated. We have computed voxel-scale whole-brain functional connectivity maps to generate a comprehensive mouse brain functional connectome. Consistent with human studies, we show that mouse brain contains mutually-interconnected connector hubs in several sub-regions of a default mode network, and in well-known integrative cortical structures. Our findings suggest the presence of evolutionarily-conserved, mutually-interconnected functional modules and cortical hubs as a fundamental feature of the mammal brain.

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