Abstract #0046
Remodeled resting state functional connectivity pattern in the default mode network and cortico striatal circuitry of GPR88 knock-out mouse brain
Tanzil Mahmud Arefin 1,2 , Anna Mechling 2,3 , Thomas Bienert 2 , Hsu-Lei Lee 2 , Sami Ben Hamida 4 , Dominik V. Elverfeldt 2 , Jrgen Hennig 2 , Brigitte Kieffer 5,6 , and Laura-Adela Harsan 2
1
Computational Neuroscience, Bernstein Center
Freiburg, University of Freiburg, Freiburg, Baden -
Wrttemberg, Germany,
2
Diagnostic
Radiology, Medical Physics, University Hospital
Freiburg, Freiburg, Baden - Wrttemberg, Germany,
3
Faculty
of Biology, University of Freiburg, Freiburg, Baden -
Wrttemberg, Germany,
4
4Institut
de Gntique et de Biologie Molculaire et Cellulaire,
Strasbourg, France,
5
Douglas
Research Center, McGill University, Montreal, Canada,
6
Institut
de Gntique et de Biologie Molculaire et Cellulaire,
Strasbourg, France
Functional communication between brain regions plays a
key role in complex cognitive process. Emerging studies
show that rsfMRI can reveal the modifications in
functional brain connectivity due to psychiatric
disorders or drug effects. This study was aimed to
scrutinize the functional connectivity modifications in
GPR88 Knock Out (KO) mice using rsfMRI technique, which
has not been reported yet and might be interesting in
the perspective of neurological or psychiatric disorders
and drug research.
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