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Abstract #0049

Does vasomotion alter functional connectivity? A multi-modal study using Optical Imaging Spectroscopy and BOLD f MRI

Priya Patel 1 , Aneurin James Kennerley 1 , Luke Boorman 1 , Myles Jones 1 , and Jason Berwick 1

1 Psychology, University of Sheffield, Sheffield, South Yorks, United Kingdom

Slow cerebral oscillations, 0.1 Hz, termed as vasomotion, could confound neurovascular coupling within resting state fMRI BOLD signal, therefore inferring connectivity changes from BOLD fMRI signal in disease states problematic. We aim to utilize a systematic analysis of the BOLD fMRI signal and 2 - dimensional optical imaging spectroscopy (2D-OIS) data to examine the magnitude and spatial correlations of fluctuations in BOLD fMRI signals and hemodynamics following manipulation of the systemic blood pressure in anesthetized rodents; this will in part emulate physiological conditions such as in disease states. Changing the systemic blood pressure modulated the 0.1Hz vasomotion signal and we have seen a difference in the inferred connectivity maps before and after this change.

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