Can resting state fMRI be used to map cerebrovascular reactivity?
Peiying Liu 1 , Babu G Welch 2 , Darlene King 2 , Yang Li 1 , Marco Pinho 1,3 , and Hanzhang Lu 1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
Surgery Clinic, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
of Radiology, University of Texas Southwestern Medical
Center, Texas, United States
Hypercapnia inhalation is commonly used to map
cerebrovascular reactivity(CVR) in clinical research
studies. However, gas inhalation may not be feasible for
acute patients (e.g., acute stoke, traumatic brain
injury). In this work, we aim to explore an alternative
approach without gas inhalation. We hypothesize that
global BOLD signal can serve as a reliable regressor for
CVR estimation from the resting state BOLD data. We
showed that the resting CVR generated by this method is
reproducible, and of similar physiological origin as
CO2-inhalation-derived CVR. This method might be a
reliable surrogate of CVR mapping when hypercapnia
inhalation is not feasible.
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