Abstract #0058
Quantitative proton MR spectroscopy of non-enhancing lesions and pre-lesional tissue in early multiple sclerosis
Ivan I Kirov 1,2 , Shu Liu 1,2 , William E Wu 1,2 , Assaf Tal 3 , Matthew Davitz 1,2 , Henry Rusinek 1,2 , Joseph Herbert 4 , and Oded Gonen 1,2
1
Radiology, New York University School of
Medicine, New York, NY, United States,
2
Center
for Advanced Imaging Innovation and Research (CAI2R),
New York University, New York, NY, United States,
3
Chemical
Physics, Weizmann Institute of Science, Israel,
4
Neurology,
New York University School of Medicine, New York, NY,
United States
We studied the metabolism associated with pre-lesional
tissue and non-enhancing lesions in early
relapsing-remitting multiple sclerosis, using high
spatial resolution proton magnetic resonance
spectroscopic imaging at 3T. Absolute quantification
with stringent partial volume correction was applied to
measure metabolite levels in lesions under 1 cm
3
.
Pre-lesional tissue exhibited lesion-like metabolism for
the glial markers Cho, Cr and mI, but in contrast,
showed higher NAA. A statistically significant
correlation between the degree of T1-hypointensity and
metabolism was observed for NAA, but the relationship
did not hold when pre-lesional tissue was excluded from
the analysis.
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