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Abstract #0058

Quantitative proton MR spectroscopy of non-enhancing lesions and pre-lesional tissue in early multiple sclerosis

Ivan I Kirov 1,2 , Shu Liu 1,2 , William E Wu 1,2 , Assaf Tal 3 , Matthew Davitz 1,2 , Henry Rusinek 1,2 , Joseph Herbert 4 , and Oded Gonen 1,2

1 Radiology, New York University School of Medicine, New York, NY, United States, 2 Center for Advanced Imaging Innovation and Research (CAI2R), New York University, New York, NY, United States, 3 Chemical Physics, Weizmann Institute of Science, Israel, 4 Neurology, New York University School of Medicine, New York, NY, United States

We studied the metabolism associated with pre-lesional tissue and non-enhancing lesions in early relapsing-remitting multiple sclerosis, using high spatial resolution proton magnetic resonance spectroscopic imaging at 3T. Absolute quantification with stringent partial volume correction was applied to measure metabolite levels in lesions under 1 cm 3 . Pre-lesional tissue exhibited lesion-like metabolism for the glial markers Cho, Cr and mI, but in contrast, showed higher NAA. A statistically significant correlation between the degree of T1-hypointensity and metabolism was observed for NAA, but the relationship did not hold when pre-lesional tissue was excluded from the analysis.

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