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Abstract #0059

In vivo quantitative MR spectroscopy using Relaxation Enhancement: unassigned brain metabolite resonances at 21T upon Stroke

Tangi Roussel 1 , Jens T Rosenberg 2,3 , Samuel C Grant 2,3 , and Lucio Frydman 1

1 Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2 National High Magnetic Field Laboratory, Tallahassee, Florida, United States, 3 Chemical & Biomedical Engineering, The Florida State University, Tallahassee, Florida, United States

The effective T1 of macromolecular resonances may be shortened using spectrally selective excitations. Relaxation Enhanced (RE) MRS exploits this in vivo, revealing apparent T1 reductions -particularly for exchanging sites. This paper presents localized spin-echo sequences based on RE MRS and dedicated to quantify in vivo metabolites resonating downfield from the water peak. RE enhanced the global spectral quality allowing us to characterize poorly assigned resonances such as ATP, Gln, GSH, NAA, PCr and estimate the changes upon stroke. This technique provides an alternative to conventional in vivo 1HMRS and allows the exploration of the downfield spectral region, potentially revealing important biomarkers.

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