Abstract #0059
In vivo quantitative MR spectroscopy using Relaxation Enhancement: unassigned brain metabolite resonances at 21T upon Stroke
Tangi Roussel 1 , Jens T Rosenberg 2,3 , Samuel C Grant 2,3 , and Lucio Frydman 1
1
Department of Chemical Physics, Weizmann
Institute of Science, Rehovot, Israel,
2
National
High Magnetic Field Laboratory, Tallahassee, Florida,
United States,
3
Chemical
& Biomedical Engineering, The Florida State University,
Tallahassee, Florida, United States
The effective T1 of macromolecular resonances may be
shortened using spectrally selective excitations.
Relaxation Enhanced (RE) MRS exploits this in vivo,
revealing apparent T1 reductions -particularly for
exchanging sites. This paper presents localized
spin-echo sequences based on RE MRS and dedicated to
quantify in vivo metabolites resonating downfield from
the water peak. RE enhanced the global spectral quality
allowing us to characterize poorly assigned resonances
such as ATP, Gln, GSH, NAA, PCr and estimate the changes
upon stroke. This technique provides an alternative to
conventional in vivo 1HMRS and allows the exploration of
the downfield spectral region, potentially revealing
important biomarkers.
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