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Abstract #0060

Accelerated Echo Planer J-resolved spectroscopic imaging of Insular Cortex and Putamen in Obstructive sleep apnea

Manoj Kumar Sarma 1 , Paul Michael Macey 2 , Rajakumar Nagarajan 1 , Ravi Aysola 3 , and M.Albert Thomas 1

1 Radiological Sciences, UCLA School of Medicine, Los angeles, CA, United States, 2 School of Nursing, UCLA School of Medicine, Los angeles, CA, United States, 3 Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los angeles, CA, United States

Patients with obstructive sleep apnea syndrome (OSAS) shows significant autonomic and neuropsychologic deficits, which may derive from damage to insular cortices and putamen, two key limbic structures that serve such functions. Here we examined neurochemical changes in the insular cortices and putamen of OSAS patients to provide indications of the nature of tissue changes using compressed sensing based 4D echo-planar J-resolved spectroscopic imaging. tCho/Cr ratio was reduced significantly in right insular cortex, and Glx/Cr, Glu/Cr ratios increased in the left insular cortex and right putamen respectively. Significantly increased GABA/Cr was found in right insular cortex with both insular cortex and putamen showing decreased tNAA, NAA and increased mI bilaterally. These findings will provide insight into structural brain changes in OSAS, and suggest possible treatment options to address common central nervous system symptoms in the sleep disorder.

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