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Abstract #0061

Validation of accelerated TE-Averaged Echo-Planar Spectroscopic Imaging in Healthy and HIV youths

Zohaib Iqbal 1 , Neil E. Wilson 1 , Brian L. Burns 1 , Margaret A. Keller 1 , and Michael Albert Thomas 1

1 University of California - Los Angeles, Los Angeles, California, United States

The purpose of this study was to evaluate regional metabolite differences in perinatally HIV-infected youths using accelerated TE-averaged echo-planar Spectroscopic Imaging (accelerated TEA-EPSI), which acquires TE-averaged spectroscopic images from multiple slices in a clinically feasible scan time. The results show significantly increased Ch/Cr in the basal ganglia and increased Glu/Cr in the occipital gray regions, as well as a trend for decreased NAA/Cr in the frontal white region in the brain of HIV-infected youths when compared to that of healthy youths. This is consistent with previous findings. Overall, this study demonstrates the potential of accelerated TEA-EPSI for investigating neurological diseases.

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