Multiband MR spectroscopic imaging in human brain

A multiband spectroscopic imaging acquisition is described and applied at 3T. This method acquires simultaneous multi-slice spectroscopic images with minimal chemical shift dispersion error by virtue of a cascaded excitation spin echo sequence. The phase toggling of the excitation pulses creates an RF based k-space separation of the individual slices that can be spatially reconstructed by virtue of the sensitivity of the receive array. In conjunction with a non-selective inversion recovery, this method enables detection of abnormalities in metabolites at the cortical edge. This method is demonstrated in control and neurological patients at 3T.

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