Abstract #0065
MRI Tracked Tumor Physiology in the Hours after 20 Gy Single-Fraction Radiation
Rasha M. Elmghirbi 1,2 , Stephen L. Brown 3 , Tavarekere N. Nagaraja 4 , Madhava P. Aryal 2,5 , Kelly Ann Keenan 4 , Swayamprav Panda 2 , Hassan Bagher-Ebadian 2 , and James R. Ewing 1,2
1
Physics, Oakland University, Rochester, MI,
United States,
2
Neurology,
Henry Ford Health System, Detroit, MI, United States,
3
Radiation
Oncology, Henry Ford Health System, Detroit, MI, United
States,
4
Anesthesiology,
Henry Ford Health System, Detroit, MI, United States,
5
Radiation
Oncology, University of Michigan, Ann Arbor, MI, United
States
The acute response in a U251 rat model of embedded
cerebral tumor high-dose radiotherapy (HD-RT) is studied
by measuring blood flow and vascular parameters in the
tumor, and tissue compression in the periphery of the
tumor. At 2 and 4 hours post HD-RT a profound decrease
in tumor blood flow accompanies a significant decrease
in extracellular space in both the tumor and its
periphery. Decoupling of tissue compression and blood
flow occurs about 8 hours after HD-RT.
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